解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Pediatric thromboembolism (≤18 years) is very rare (0.07-0.14/10,000/year) but may be more prevalent in children with severe thrombophilia (protein C, protein S or antithrombin deficiency). The aim of this study was to define the prevalence and clinical characteristics of pediatric thrombosis in subjects with inherite...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.210666
更新日期:2019-12-01 00:00:00
abstract::Children with immune thrombocytopenia for ≥6 months completing a romiplostim study received weekly subcutaneous romiplostim (1-10 μg/kg targeting platelet counts of 50-200×109/L) in this extension to examine romiplostim's long-term safety and efficacy. Sixty-five children received romiplostim for a median of 2.6 years...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.202283
更新日期:2019-11-01 00:00:00
abstract::It has been postulated that monitoring measurable residual disease (MRD) could be used as a surrogate marker of progression-free survival (PFS) in chronic lymphocytic leukemia (CLL) patients after treatment with immunochemotherapy regimens. In this study, we analyzed the outcome of 84 patients at 3 years of follow-up ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.204891
更新日期:2019-11-01 00:00:00
abstract::Hemophagocytic lymphohistiocytosis is a life-threatening systemic hyperinflammatory disorder with primary and secondary forms. Primary hemophagocytic lymphohistiocytosis is associated with inherited defects in various genes that affect the immunological cytolytic pathway. Secondary hemophagocytic lymphohistiocytosis i...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.209551
更新日期:2019-10-01 00:00:00
abstract::Normal hematopoiesis can be disrupted by the leukemic bone marrow microenvironment, which leads to cytopenia-associated symptoms including anemia, hemorrhage and infection. Thrombocytopenia is a major and sometimes fatal complication in patients with acute leukemia. However, the mechanisms underlying defective thrombo...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.214593
更新日期:2019-10-01 00:00:00
abstract::The regulation of platelets by oxidants is critical for vascular health and may explain thrombotic complications in diseases such as diabetes and dementia, but remains poorly understood. Here, we describe a novel technique combining electron paramagnetic resonance spectroscopy and turbidimetry, which has been utilized...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.208819
更新日期:2019-09-01 00:00:00
abstract::The balance between self-renewal and differentiation is crucial to ensure the homeostasis of the hematopoietic system, and is a hallmark of hematopoietic stem cells. However, the underlying molecular pathways, including the role of micro-RNA, are not completely understood. To assess the contribution of micro-RNA, we p...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.198499
更新日期:2019-09-01 00:00:00
abstract::New drugs are needed for the treatment of relapsed acute lymphoblastic leukemia and preclinical evaluation of the MEK inhibitor, selumetinib, has shown that this drug has excellent activity in those leukemias with RAS pathway mutations. The proapoptotic protein, BIM is pivotal in the induction of cell death by both se...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.185975
更新日期:2019-09-01 00:00:00
abstract::Twice-weekly carfilzomib is approved at 27 and 56 mg/m2 to treat relapsed multiple myeloma patients. In the phase III study ARROW, once-weekly 70 mg/m 2 carfilzomib prolonged the median progression-free survival of relapsed multiple myeloma patients in comparison with twice-weekly 27 mg/m2 carfilzomib, without adding ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.208272
更新日期:2019-08-01 00:00:00
abstract::Proteolysis targeting chimeric molecule ARV 825 causes ubiquitination of bromodomains resulting in their efficient degradation by proteasome activity. Bromodomain degradation down-regulates MYC transcription contributing to growth inhibition of various human cancers. We examined the therapeutic potential of ARV 825 ag...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.201483
更新日期:2019-06-01 00:00:00
abstract::Germline RUNX1 mutations lead to thrombocytopenia and platelet dysfunction in familial platelet disorder with predisposition to acute myelogenous leukemia (AML). Multiple aspects of platelet function are impaired in these patients, associated with altered expression of genes regulated by RUNX1 We aimed to identify RUN...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.188904
更新日期:2019-06-01 00:00:00
abstract::Here we critically evaluate the role of elevated hematocrit as the principal determinant of thrombotic risk in polycythemia and erythrocytosis, defined by an expansion of red cell mass. Since red cell volume determination is no longer readily available, in clinical practice, polycythemia and erythrocytosis are defined...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:10.3324/haematol.2018.210732
更新日期:2019-04-01 00:00:00
abstract::Thromboembolism is a serious complication of induction therapy for childhood acute lymphoblastic leukemia. We prospectively compared the efficacy and safety of antithrombotic interventions in the consecutive leukemia trials ALL-BFM 2000 and AIEOP-BFM ALL 2009. Patients with newly diagnosed acute lymphoblastic leukemia...
journal_title:Haematologica
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.3324/haematol.2018.194175
更新日期:2019-04-01 00:00:00
abstract::Platelets are critical to arterial thrombosis, which underlies myocardial infarction and stroke. Activated platelets, regardless of the nature of their stimulus, initiate energy-intensive processes that sustain thrombus, while adapting to potential adversities of hypoxia and nutrient deprivation within the densely pac...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.205724
更新日期:2019-04-01 00:00:00
abstract::Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which could influence vascular disease through distinct mechanisms. An overactive sympathetic nervous system is a dominant pathway that can precipitate in elevated b...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.192898
更新日期:2019-03-01 00:00:00
abstract::Asparaginase-associated pancreatitis is a life-threatening toxicity to childhood acute lymphoblastic leukemia treatment. To elucidate genetic predisposition and asparaginase-associated pancreatitis pathogenesis, ten trial groups contributed remission samples from patients aged 1.0-17.9 years treated for acute lymphobl...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.199356
更新日期:2019-03-01 00:00:00
abstract::Anemia is highly prevalent, especially in older individuals. In selected populations, anemia has been reported to be associated with impaired survival and health-related quality of life. However, data on this impact in the general population are rare. Furthermore, discussions on the optimal definition of anemia have n...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.195552
更新日期:2019-03-01 00:00:00
abstract::Spontaneous Rh blood group changes are a striking sign, reported to occur mainly in patients with hematologic disorders. Upon routine blood grouping, 2 unrelated individuals showed unexplained mixed red cell phenotype regarding the highly immunogenic c antigen (RH4), clinically relevant for blood transfusion and fetom...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.201293
更新日期:2019-03-01 00:00:00
abstract::We previously reported initial results in 102 multiple myeloma (MM) patients treated with sequential high-dose melphalan and autologous hematopoietic cell transplantation followed by 200 cGy total body irradiation with or without fludarabine 90 mg/m2 and allogeneic hematopoietic cell transplantation. Here we present l...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.200253
更新日期:2019-02-01 00:00:00
abstract::Iron recycling by macrophages is essential for erythropoiesis, but may also be relevant for iron redistribution to neighboring cells at the local tissue level. Using mice with iron retention in macrophages due to targeted inactivation of the iron exporter ferroportin, we investigated the role of macrophage iron releas...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.197517
更新日期:2019-01-01 00:00:00
abstract::Inherited bone marrow failure syndromes are experiments of nature characterized by impaired hematopoiesis with cancer and leukemia predisposition. The mutations associated with inherited bone marrow failure syndromes affect fundamental cellular pathways, such as DNA repair, telomere maintenance, or proteostasis. How t...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:10.3324/haematol.2018.196105
更新日期:2019-01-01 00:00:00
abstract::Hematologic responses to hypomethylating agents are often delayed in patients with myelodysplastic syndrome or acute myeloid leukemia. Fetal hemoglobin is a potential novel bio-marker of response: recently, we demonstrated that a high fetal hemoglobin level prior to decitabine treatment was associated with superior ou...
journal_title:Haematologica
pub_type: 临床试验,杂志文章
doi:10.3324/haematol.2017.187278
更新日期:2019-01-01 00:00:00
abstract::The detection of iron deficiency anemia is challenged by the paucity of diagnostic tests demonstrating high sensitivity and specificity. Using two biomarkers, zinc-protoporphyrin/heme and hepcidin, we established the diagnostic cut-off values for iron deficiency anemia in preschool children and women. We randomly sele...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.193243
更新日期:2018-12-01 00:00:00
abstract::The bone marrow microenvironment regulates normal and malignant hematopoiesis, but the underlying molecular mechanisms remain poorly defined. Using a chimeric mice model, we demonstrate that Twist1 deletion in the bone marrow microenvironment results in alteration of multiple niche cells as well as downregulated expre...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.190652
更新日期:2018-12-01 00:00:00
abstract::Pathological erythropoiesis with consequent anemia is a leading cause of symptomatic morbidity in internal medicine. The etiologies of anemia are complex and include reactive as well as neoplastic conditions. Clonal expansion of erythroid cells in the bone marrow may result in peripheral erythrocytosis and polycythemi...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:10.3324/haematol.2018.192518
更新日期:2018-10-01 00:00:00
abstract::The stimulation of erythrocyte formation increases the demand for iron by the bone marrow and this in turn may affect the levels of circulating diferric transferrin. As this molecule influences the production of the iron regulatory hormone hepcidin, we hypothesized that erythropoiesis-driven changes in diferric transf...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.187245
更新日期:2018-10-01 00:00:00
abstract::The immunomodulatory drugs, lenalidomide and pomalidomide yield high response rates in multiple myeloma patients, but are associated with a high rate of thrombocytopenia and increased risk of secondary hematologic malignancies. Here, we demonstrate that the immunomodulatory drugs induce self-renewal of hematopoietic p...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.188227
更新日期:2018-10-01 00:00:00
abstract::The success of hematopoietic stem cell transplantation is determined by multiple factors. Additional complexity is conferred by covariables showing time-dependent effects. We evaluated the effect of predictors on competing-risk outcomes after hematopoietic stem cell transplantation in a time-dependent manner. We analy...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.183012
更新日期:2018-09-01 00:00:00
abstract::Diseases with clonal hematopoiesis such as myelodysplastic syndrome and acute myeloid leukemia have high rates of relapse. Only a small subset of acute myeloid leukemia patients are cured with chemotherapy alone. Relapse in these diseases occurs at least in part due to the failure to eradicate leukemic stem cells or h...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.188193
更新日期:2018-08-01 00:00:00
abstract::Patients with advanced myeloma experience a high symptom burden particularly near the end of life, making timely hospice use crucial. Little is known about the quality and determinants of end-of-life care for this population, including whether potential increases in hospice use are also accompanied by "late" enrollmen...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.187609
更新日期:2018-08-01 00:00:00
abstract::Mucosa-associated lymphoid tissue (MALT) lymphoma originates from a background of diverse chronic inflammatory disorders at various anatomic sites. The genetics underlying its development, particularly in those associated with autoimmune disorders, is poorly characterized. By whole exome sequencing of 21 cases of MALT...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.191601
更新日期:2018-08-01 00:00:00
abstract::This analysis explored factors influencing survival of patients with primary refractory and relapsed peripheral T-cell lymphomas enrolled in the prospective International T-cell Project. We analyzed data from 1020 patients with newly diagnosed disease, enrolled between September 2006 and December 2015. Out of 937 pati...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.186577
更新日期:2018-07-01 00:00:00
abstract::Tissue Factor is a cell-surface glycoprotein expressed in various cells of the vasculature and is the principal regulator of the blood coagulation cascade and hemostasis. Notably, aberrant expression of Tissue Factor is associated with cardiovascular pathologies such as atherosclerosis and thrombosis. Here, we sought ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.183087
更新日期:2018-06-01 00:00:00
abstract::Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation. To date, the role played by T-cell receptor in the oncogenic transformation of developing T cells remains unclear. Here we...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2018.188359
更新日期:2018-06-01 00:00:00
abstract::In contrast to well-established hierarchical concepts of tumor stem cells, leukemia-initiating cells in B-cell precursor acute lymphoblastic leukemia have not yet been phenotypically identified. Different subpopulations, as defined by surface markers, have shown equal abilities to reconstitute leukemia upon transplant...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.167502
更新日期:2018-06-01 00:00:00
abstract::Glycoprotein VI, a major platelet activation receptor for collagen and fibrin, is considered a particularly promising, safe antithrombotic target. In this study, we show that human glycoprotein VI signals upon platelet adhesion to fibrinogen. Full spreading of human platelets on fibrinogen was abolished in platelets f...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.182972
更新日期:2018-05-01 00:00:00
abstract::Previously, we found that LDL-receptor related protein-1 on macrophages mediated shear stress-dependent clearance of von Willebrand factor. In control experiments, however, we observed that von Willebrand factor also binds to macrophages independently of this receptor under static conditions, suggesting the existence ...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.175216
更新日期:2018-04-01 00:00:00
abstract::Tyrosine kinase inhibitors (TKIs) are highly effective for the treatment of chronic myeloid leukemia (CML), but very few patients are cured. The major drawbacks regarding TKIs are their low efficacy in eradicating the leukemic stem cells responsible for disease maintenance and relapse upon drug cessation. Herein, we p...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.169946
更新日期:2018-03-01 00:00:00
abstract::Patients with anaplastic lymphoma kinase-positive anaplastic large cell lymphoma often present with B-symptoms or hemophagocytosis and generate an anti-tumor immune response. Specific serum cytokine levels or profiles may reflect the tumor burden, non-specific immune stimulation by the tumor or differences in the stre...
journal_title:Haematologica
pub_type: 杂志文章
doi:10.3324/haematol.2017.177972
更新日期:2018-03-01 00:00:00
abstract::Survival of myeloma patients has greatly improved with the use of autologous stem cell transplantation and novel agents, such as proteasome inhibitors, immunomodulatory drugs and monoclonal antibodies. Compared to bortezomib- and lenalidomide-based regimens alone, the addition of high-dose melphalan followed by autolo...
journal_title:Haematologica
pub_type: 杂志文章,评审
doi:10.3324/haematol.2017.174573
更新日期:2018-02-01 00:00:00